Citation link:
Authors:
Petkov, Y.
Title:
MAJOR DEPRESSIVE DISORDER, TYPE 2 DIABETES MELLITUS AND INFLAMMATION
Date of Issue:
2024
Is Part of:
Trakia Journal of Sciences: Series Biomedical Sciences, Vol. 22, No 4, pp 345-353
Publisher:
Тракийски университет - Стара Загора
Identifiers:
1313-3551 [issn]
Type:
Article
Language:
eng
Subject:
Inflammation; depression; diabetes
Abstract:
Inflammation may play a key role in the pathogenesis of both depression and type 2 diabetes. However, elevated levels of circulating IL-6 are an independent predictor of type 2 diabetes and are thought to occurwith the development of insulin resistance and β-cell dysfunction.There is no evidence linking IL-6 to β-cell dysfunction and eventual β-cell apoptosis. Elevated levels of IL-6 are always associated with increased hypothalamic-pituitary-adrenal (HPA) activity in depression.This increases cortisol, which then triggers TDO and reduces the availability of tryptophan for the production of melatonin, NAS and serotonin. Therefore, IL-6 contributes to the regulation of important biological pathways that underlie stress and the subsequent depression that results from stress.
